Many people don’t like Touchwiz on Samsung phones due to the lag it often introduces. On the Note 4 there really isn’t any lag. Below are 2 setups on my Note 4. First up are screen shots using Touchwiz. Then from Nova Launcher. Whenever you use a third party launcher you lose some of widgets like the monthly calendar and location widgets shown below that I really like.

The above screen is a left swipe on the Touchwiz home screen. You don’t get this when using Nova Launcher. Now below is Nova Launcher.

So which style do you prefer?